Polimorfismos de nucleótido simple en hormonas asociadas al crecimiento muscular en ovinos criollos colombianos
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Sarmiento Cardenas, P., Castro Molina, S., Ortiz Sanchez, Y., & Ariza Botero, M. (2023). Polimorfismos de nucleótido simple en hormonas asociadas al crecimiento muscular en ovinos criollos colombianos. NOVA, 21(40), 57-74. https://doi.org/10.22490/24629448.6916
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Autores
Paul Nicolas Sarmiento Cardenas
https://orcid.org/0000-0002-5431-5126
https://orcid.org/0000-0002-5431-5126
Susan Lorena Castro Molina, Msc
https://orcid.org/0000-0001-7003-6162
https://orcid.org/0000-0001-7003-6162
Yurany Teresa Ortiz Sanchez, Msc
https://orcid.org/0000-0001-6928-2219
https://orcid.org/0000-0001-6928-2219
Maniel Fernando Ariza Botero, PhD
https://orcid.org/0000-0001-5654-6510
https://orcid.org/0000-0001-5654-6510
Resumen
Objetivo. Determinar Polimorfismos de Nucleótido Simple (SNPs) presentes en los genes de la Hormona del Crecimiento (HC) y del Factor de Crecimiento Semejante a la Insulina 1 (IGF-1) y su asociación con el crecimiento muscular en ovinos de pelo criollos colombianos. Materiales y métodos. Se seleccionó una población de 100 ovinos, de tres regiones diferentes: Valles interandinos, Piedemonte Llanero y departamento de Córdoba, sometidos a diferentes sistemas de producción. La identificación de polimorfismos en los genes se realizó mediante las técnicas de Reacción en Cadena de la Polimerasa (PCR) y de Polimorfismo Conformacional de Cadena Sencilla (SSCP). Resultados. Se identificaron los genotipos AA, AB y BB para dichos genes. Las frecuencias alélicas para los marcadores HC, IGF-1 (IGFov-1, IGF1ov-2 e IGF1ov-3) fueron
de 58.9, 36.87, 53.76 y 56.81% para el alelo A, respectivamente, y de 41.41, 63.13, 46.24 y 43.18% para el alelo B, respectivamente. Asimismo, se
determinaron las frecuencias genotípicas para cada marcador a nivel poblacional, calculado a partir del equilibrio de Hardy-Weinberg con un análisis de correlación Fis. Conclusión. Los marcadores seleccionados presentaron un alto nivel de homología en la población seleccionada, lográndose determinar que existe un alto porcentaje de individuos heterocigotos con base a los marcadores evaluados.
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.
Así mismo, los autores mantienen sus derechos de propiedad intelectual sobre los artículos.
Referencias
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https://doi.org/10.3390/nu7010360
9. J. Li, A. J. Control of growth hormone receptor and insulin-like growth factor-I expression by cortisol in ovine fetal skeletal muscle. The Journal of Physiology, 2002; 541(2), 581-589 https://doi.org/10.1113/jphysiol.2002.016402
https://doi.org/10.1113/jphysiol.2002.016402
10. Mohammad Koohmaraie, MP. Meat tenderness and muscle growth: is there any relationship. Meat science. 2002; 62(3), 345-352. https://doi.org/10.1016/S0309-1740(02)00127-4
https://doi.org/10.1016/S0309-1740(02)00127-4
11. Díaz AÁ. Esteban, H. P., Hernández, T. D. L. C. M., Torres, J. Q., & Puzo, A. S. Fisiología animal aplicada. Editorial Universidad de Antioquia. 2009.
12. Devesa J, Devesa P, Reimunde P. Hormona de crecimiento: acciones y aplicaciones preventivas y terapéuticas. Medicina Clínica, 2010; 135(14), 665-670. https://doi.org/10.1016/j.medcli.2009.10.017
https://doi.org/10.1016/j.medcli.2009.10.017
13. Rajni Kumari, R. K. GENETIC POLYMORPHISM OF GROWTH HORMONE GENE IN NATIVE SHEEP BREEDS OF INDIA. The Indian Journal of Small Ruminants. 2014. Disponible en: https://indianjournals.com/ijor.aspx?target=ijor:ijsr&volume=20&issue=2&article=003
14. Valencia, C. F. Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep. Trop Anim Health Prod, 2022; 54 - 82. doi:https://doi.org/10.1007/s11250-022-03086-x
https://doi.org/10.1007/s11250-022-03086-x
15. Devesa J, Almengló C, Devesa P. Multiple effects of growth hormone in the body: is it really the hormone for growth?. Clinical Medicine Insights: Endocrinology and Diabetes. 2016; 9, CMED-S38201. https://doi.org/10.4137/CMED.S38201
https://doi.org/10.4137/CMED.S38201
16. Sebastiano, L. C. Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep. Veterinary and Animal Science. 2020; doi:https://doi.org/10.1016/j.vas.2019.100084
https://doi.org/10.1016/j.vas.2019.100084
17. Karadag, O. The polymorphism of insulin-like growth factor-1 receptor (IGF-1R) gene in meat-type Lambs in Turkey: I. Effect on growth traits and body measurements. Small Ruminant Research. 2022; 215. doi:https://doi.org/10.1016/j.smallrumres.2022.106765
https://doi.org/10.1016/j.smallrumres.2022.106765
18. Simal R S. Hormona del crecimiento (GH). Fisiologia humana II. 2012. Disponible en: http://www.webfisio.es/fisiologia/endocrino/textos/gh.htm#e31 ISBN: 84-688-1218-8.
19. Beermann D. H. Physiology. Dikeman M, Devine C editor. Encyclopedia of Meat Sciences. 2nd ed Kansas, Manhattan; USA, Hamilton; New Zeland 2014.
20. Altwaty NH, S. L. Single nucleotide polymorphisms in the growth hormone receptor gene and Alu1 polymorphisms in the diacylglycerol acyltransferase 1 gene as related to meat production in sheep. Vet World. 2020; 884-889. doi: 10.14202/vetworld.2020.884-889
https://doi.org/10.14202/vetworld.2020.884-889
21. Shakweer, W. A.-R. Cloning, nucleotide sequencing, and bioinformatics analyses of growth hormone mRNA of Assaf sheep and Boer goats reared in Egypt. J Genet Eng Biotechnol, 2020; 18- 30. doi:https://doi.org/10.1186/s43141-020-00046-6
https://doi.org/10.1186/s43141-020-00046-6
22. Marwal A, Gaur Rajarshi. Molecular Markers: Tools for Genetic Analysis. Animal Biotechnology, 2nd Edition Models in Discovery and Translation. 2020; pp.353-372. Disponible en: https://www.researchgate.net/publication/342330547_Molecular_Markers_Tools_for_Genetic_Analysis
https://doi.org/10.1016/B978-0-12-811710-1.00016-1
23. Chekol C, Gebreyohannes M. Application and current trends of biotechnology: a brief review. Austin Journal of Biotechnology & Bioengineering, 2018; vol. 5, no 1, p. 1-8. Disponible en: https://biotechnology.report/Resources/Whitepapers/28d904dc-b8e3-4b1a-9c76-bf32a6734c47_fulltext_ajbtbe.pdf
24. E. Armstrong, G. C. Novel genetic polymorphisms associated with carcass traits in grazing Texel sheep. Meat Science, 2018; 202-208. doi:https://doi.org/10.1016/j.meatsci.2018.06.014
https://doi.org/10.1016/j.meatsci.2018.06.014
25. Koopaee H K, Koshkoiyeh A E. SNPs Genotyping technologies and their applications in farm animals breeding programs. Brazilian Archives of Biology and Technology, 2014; 57(1), 87-95. Disponible en: https://www.scielo.br/j/babt/a/fSn5pdNkvvLk9BMxhhfdKcd/?format=pdf&lang=en ISSN 1516-8913
https://doi.org/10.1590/S1516-89132014000100013
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