Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda

Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda

Publicado 2022-12-19

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Vol. 20 Núm. 39 (2022): Julio - Diciembre
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Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda. (2022). NOVA, 20(39), 163-180. https://doi.org/10.22490/24629448.6593
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Así mismo,  los autores mantienen sus derechos de propiedad intelectual sobre los artículos.  

Claudia Andrea Cruz Baquero
Universidad Colegio Mayor de Cundinamarca
    http://orcid.org/0000-0003-1041-9609

    David Andrés Bernal Estévez
    Fundación Salud de los Andes
      https://orcid.org/0000-0002-7330-0333

      Estefania Cuta Hernández
      Universidad Colegio Mayor de Cundinamarca
        Mostrar biografía de los autores

        La citometría de flujo (CMF) es una técnica que permite el análisis multiparamétrico de poblaciones celulares, siendo esencial en la investigación biomédica y como herramienta diagnóstica. Esta técnica se caracteriza por tener una alta sensibilidad y rapidez, evaluando en la población de interés características como tamaño, granularidad, complejidad del citoplasma celular y expresión de proteínas que permiten la diferenciación fenotípica y funcional de las células.

         Actualmente se han logrado avances notables empleando la CMF, lo que ha permitido diferenciar poblaciones celulares de forma más específica y subclasificarlas mediante la conjugación de diversos anticuerpos monoclonales antígeno-específicos, capaces de reconocer múltiples proteínas de membrana. Por estas razones, esta técnica ha adquirido importancia en el diagnóstico y seguimiento de enfermedades y anomalías hematológicas, como leucemias, síndromes mielodisplásicos y síndromes mieloproliferativos, entre otras.

         En este contexto, la presente revisión se enfoca en los avances en la implementación de la CMF en la Enfermedad Mínima Residual (EMR) presente en la Leucemia Linfoblástica Aguda (LLA), la cual es una población mínima leucémica que se detecta en un paciente después de suministrar un tratamiento oncológico, donde se evalúa su eficacia, el riesgo de una recaída y el proceso de remisión completa.

         

         

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