Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda

Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda

Published 2022-12-19

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Vol. 20 No. 39 (2022): July-December
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Cruz Baquero, C. A., Bernal Estévez, D. A., & Hernández, E. C. (2022). Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda. NOVA, 20(39), 163-180. https://doi.org/10.22490/24629448.6593
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Claudia Andrea Cruz Baquero
Universidad Colegio Mayor de Cundinamarca
    http://orcid.org/0000-0003-1041-9609

    David Andrés Bernal Estévez
    Fundación Salud de los Andes
      https://orcid.org/0000-0002-7330-0333

      Estefania Cuta Hernández
      Universidad Colegio Mayor de Cundinamarca
        Show authors biography

        Flow cytometry (FCM) is a technique that allows multiparametric analysis of cell populations, which is essential in biomedical research and as a diagnostic tool. This technique is characterized by high sensitivity and speed, evaluating in the population of interest characteristics such as size, granularity, the complexity of the cell cytoplasm, and proteins that allow phenotypic and functional differentiation.

        Remarkable progress has now been made using FCM, which has made it possible to identify cell populations more specifically and sub-classify them through the conjugation of various antigen-specific monoclonal antibodies capable of recognizing a complete set of proteins. For these reasons, this technique has become important in the diagnosis and monitoring of diseases and hematological abnormalities, such as leukemia, myelodysplastic syndromes, and myeloproliferative syndromes, among others.

         In this context, this review focuses on advances in the implementation of CMF in Minimal Residual Disease (MRD) present in Acute Lymphoblastic Leukemia (ALL), which is a minimal leukemic population that is detected in a patient after providing cancer treatment, where its effectiveness, the risk of relapse and the complete remission process are evaluated.

         

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