Efectividad de enjuagues bucales contra virus de la familia coronavirus

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Autores

Ariana Lucía Lozada Martínez https://orcid.org/0000-0001-5038-4581
Andrea Alvarez Ojeda https://orcid.org/0000-0002-8883-7010
Stella Pupo Marrugo https://orcid.org/0000-0001-5897-0542
Antonio Diaz Caballero https://orcid.org/0000-0001-9693-2969

Resumen

 La aparición del virus Sars-CoV-2 y la enfermedad Covid-19 han provocado un estado de emergencia en el sistema de salud. Teniendo en cuenta el potencial de la saliva como material contaminante, la práctica odontológica fue una de las áreas que se vio afectada debido  al uso de instrumentos que pueden esparcir aerosoles y salpicaduras que contienen microorganismos hacia el medio ambiente. Por esta razón, conociendo su potencial en la inactivación de patógenos, se propuso la utilización de  enjuagues bucales en la práctica clínica  previo a la realización de procedimientos dentales, sin embargo la evidencia no es clara respecto a su efectividad.  Objetivo: establecer el estado de evidencia actual del efecto de los enjuagues bucales sobre los coronavirus que se encuentran en cavidad. Métodos: se realizó una revisión sistemática siguiendo todos los parámetros descritos en las Directrices PRISMA basada en información obtenida en los buscadores Science direct, Pubmed y Dentistry and Oral Science Source. Los criterios de selección incluyeron  estudios in vivo e in vitro de texto completo que evidenciaron la efectividad del enjuague bucal contra coronavirus. Resultados: se obtuvieron 90 artículos, de los cuales sólo 12 cumplían con los criterios de inclusión,8 in vitro y 4 in vivo,  que fueron sometidos a la evaluación de calidad metodológica utilizando la lista de verificación de evaluación crítica del JBI. Conclusiones: Los resultados sugieren que la povidona yodada es efectiva para la inactivación del virus Sars-coV-2 en todas sus concentraciones. 


 

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Licencia Creative Commons
NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Así mismo,  los autores mantienen sus derechos de propiedad intelectual sobre los artículos.  

Referencias

1. Seyed Hosseini E, Riahi Kashani N, Nikzad H, Azadbakht J, Hassani Bafrani H, Haddad Kashani H. The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies. Virology [Internet]. 2020 Dec [cited 2021 Jan 24];551:1-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513802/
https://doi.org/10.1016/j.virol.2020.08.011

2. Ge Z, Yang L, Xia J, Fu X, Zhang Y. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B [Internet]. 2020 Mar 16 [cited 2021 Jan 24];1-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089481/

3. Tu Y-F, Chien C-S, Yarmishyn AA, Lin Y-Y, Luo Y-H, Lin Y-T, et al. A Review of SARS-CoV-2 and the Ongoing Clinical Trials. Int J Mol Sci [Internet]. 2020 Apr 10 [cited 2020 Oct 12];21(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177898/
https://doi.org/10.3390/ijms21072657

4. Contini C, Nuzzo MD, Barp N, Bonazza A, Giorgio RD, Tognon M, et al. The novel zoonotic COVID-19 pandemic: An expected global health concern. J Infect Dev Ctries [Internet]. 2020 Mar 31 [cited 2021 Jan 24];14(03):254-64. Available from: https://jidc.org/index.php/journal/article/view/32235085
https://doi.org/10.3855/jidc.12671

5. Baghizadeh Fini M. Oral saliva and COVID-19. Oral Oncol [Internet]. 2020 Sep [cited 2021 Jan 20];108:104821. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250788/
https://doi.org/10.1016/j.oraloncology.2020.104821

6. Tavares C de AM, Avelino-Silva TJ, Benard G, Cardozo FAM, Fernandes JR, Girardi ACC, et al. ACE2 Expression and Risk Factors for COVID-19 Severity in Patients with Advanced Age. Arq Bras Cardiol [Internet]. 2020 Oct [cited 2021 Jan 24];115(4):701-7. Available from: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2020001200701&lng=en&nrm=iso&tlng=en
https://doi.org/10.36660/abc.20200487

7. Retamal-Valdes B, Soares GM, Stewart B, Figueiredo LC, Faveri M, Miller S, et al. Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial. Braz Oral Res [Internet]. 2017 [cited 2021 Feb 14];31(0). Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100221&lng=en&tlng=en
https://doi.org/10.1590/1807-3107bor-2017.vol31.0021

8. Villani FA, Aiuto R, Paglia L, Re D. COVID-19 and Dentistry: Prevention in Dental Practice, a Literature Review. Int J Environ Res Public Health [Internet]. 2020 Jun [cited 2021 Jan 25];17(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344885/
https://doi.org/10.3390/ijerph17124609

9. Kohn WG, Collins AS, Cleveland JL, Harte JA, Eklund KJ, Malvitz DM. Guidelines for infection control in dental health-care settings-2003. 2003;
https://doi.org/10.14219/jada.archive.2004.0019

10. Martínez Lamas L, Diz Dios P, Pérez Rodríguez MT, Del Campo Pérez V, Cabrera Alvargonzalez JJ, López Domínguez AM, et al. Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests. Oral Dis. 2020 Jul 2;
https://doi.org/10.1111/odi.13526

11. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev [Internet]. 2015 Jan 1 [cited 2021 Feb 14];4(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320440/
https://doi.org/10.1186/2046-4053-4-1

12. Moola S. Chapter 7: systematic reviews of etiology and risk in: Aromataris E, Munn Z, eds Joanna Briggs institute reviewer's manual. The Joanna Briggs Institute, 2017.

13. Negri EC, Mazzo A, Martins JCA, Pereira GA, Almeida RG dos S, Pedersoli CE. Clinical simulation with dramatization: gains perceived by students and health professionals. Rev Lat Am Enfermagem [Internet]. 2017 Aug 3 [cited 2021 Jul 20];25:e2916. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626175/
https://doi.org/10.1590/1518-8345.1807.2916

14. Santos WM dos, Secoli SR, Püschel VA de A. The Joanna Briggs Institute approach for systematic reviews. Rev Lat Am Enfermagem [Internet]. 2018 Nov 14 [cited 2021 Jul 20];26(0). Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692018000100701&lng=en&tlng=en
https://doi.org/10.1590/1518-8345.2885.3074

15. Mukherjee PK, Esper F, Buchheit K, Arters K, Adkins I, Ghannoum MA, et al. Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections. BMC Infect Dis [Internet]. 2017 Jan 14 [cited 2021 Feb 15];17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237564/
https://doi.org/10.1186/s12879-016-2177-8

16. Seneviratne CJ, Balan P, Ko KKK, Udawatte NS, Lai D, Ng DHL, et al. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection [Internet]. 2020 Dec 14 [cited 2021 Feb 15];1-7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734110/

17. Gottsauner MJ, Michaelides I, Schmidt B, Scholz KJ, Buchalla W, Widbiller M, et al. A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2. Clin Oral Investig [Internet]. 2020 Sep 2 [cited 2020 Oct 6];1-7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464055/

18. Eggers M, Koburger-Janssen T, Eickmann M, Zorn J. In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens. Infect Dis Ther [Internet]. 2018 Jun [cited 2020 Sep 9];7(2):249-59. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986684/
https://doi.org/10.1007/s40121-018-0200-7

19. Eggers M, Eickmann M, Zorn J. Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA). Infect Dis Ther [Internet]. 2015 Dec [cited 2020 Sep 27];4(4):491-501. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675768/
https://doi.org/10.1007/s40121-015-0091-9

20. Pelletier J, Tessema B, Westover J, Frank S, Brown S, Capriotti J. In Vitro Efficacy of Povidone-Iodine Nasal And Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). medRxiv [Internet]. 2020 May 26 [cited 2020 Oct 6];2020.05.25.20110239. Available from: https://www.medrxiv.org/content/10.1101/2020.05.25.20110239v1
https://doi.org/10.1101/2020.05.25.20110239

21. Anderson DE, Sivalingam V, Kang AEZ, Ananthanarayanan A, Arumugam H, Jenkins TM, et al. Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease. Infect Dis Ther. 2020 Sep;9(3):669-75.
https://doi.org/10.1007/s40121-020-00316-3

22. Kariwa H, Fujii N, Takashima I. Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents. Dermatol Basel Switz. 2006;212 Suppl 1:119-23.
https://doi.org/10.1159/000089211

23. Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Rapid In‐Vitro Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) Using Povidone‐Iodine Oral Antiseptic Rinse. J Prosthodont [Internet]. 2020 Jul [cited 2020 Sep 9];29(6):529-33. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jopr.13209
https://doi.org/10.1111/jopr.13209

24. Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of In Vitro Inactivation of SARS CoV-2 with Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses. J Prosthodont [Internet]. 2020 [cited 2020 Sep 9];29(7):599-603. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jopr.13220
https://doi.org/10.1111/jopr.13220

25. Wood A, Payne D. The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses. J Hosp Infect. 1998 Apr;38(4):283-95.
https://doi.org/10.1016/S0195-6701(98)90077-9

26. Moosavi M-S, Aminishakib P, Ansari M. Antiviral mouthwashes: possible benefit for COVID-19 with evidence-based approach. J Oral Microbiol [Internet]. [cited 2020 Sep 29];12(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482897/
https://doi.org/10.1080/20002297.2020.1794363

27. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci [Internet]. 2020 Mar 3 [cited 2021 May 8];12. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054527/
https://doi.org/10.1038/s41368-020-0075-9

28. Jing JLJ, Pei Yi T, Bose RJC, McCarthy JR, Tharmalingam N, Madheswaran T. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations. Int J Environ Res Public Health [Internet]. 2020 May [cited 2021 Feb 15];17(9). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246736/
https://doi.org/10.3390/ijerph17093326

29. COVID-19 and Oral Surgery: A narrative review of preoperative mouth rinses [Internet]. [cited 2021 May 8]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871429/

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