Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos.

Caenorhabditis elegans as an infection model for the study of antimicrobials.

Publicado 2021-08-23

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Vol. 19 Núm. 36 (2021): Enero - Junio
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Sánchez Mora, R. M., Rodríguez Morales, D., & Lozano Jiménez, Y. Y. (2021). Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos. REVISTA NOVA , 19(36). https://revistas.unicolmayor.edu.co/index.php/nova/article/view/1834
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Así mismo,  los autores mantienen sus derechos de propiedad intelectual sobre los artículos.  

Ruth Mélida Sánchez Mora
Universidad Colegio Mayor de Cundinamarca
    https://orcid.org/0000-0002-0572-8418

    Dayana Rodríguez Morales
    Universidad Colegio Mayor de Cundinamarca
      https://orcid.org/0000-0002-9511-8583

      Yenny Yolanda Lozano Jiménez
      Universidad de La Salle
        https://orcid.org/0000-0002-5419-2971

        Mostrar biografía de los autores

        Ruth Mélida Sánchez Mora,

        Grupo biotecnología y genética UCMC. Universidad Colegio Mayor de Cundinamarca. CvLAC https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000464252, Google académico: https://scholar.google.es/citations?hl=es&user=6yJh6uIAAAAJ

        Dayana Rodríguez Morales,

        Grupo Biotecnología y genética UCMC. Universidad Colegio Mayor de Cundinamarca. CvLAC:https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000176007. Google académico: https://scholar.google.es/citations?hl=es&user=soG6YX4AAAAJ

        Yenny Yolanda Lozano Jiménez,

        Universidad de La Salle, Departamento de Ciencias Básicas. Grupo entomología y enfermedades transmitidas por vectores CvLAC https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000858790. Google académico: https://scholar.google.es/citations?hl=es&user=pErlypQAAAAJ

        A pesar de algunas limitaciones éticas, los animales juegan un papel importante como anfitriones sustitutos para investigar los mecanismos fisiopatológicos de enfermedades con el fin de indagar en ellos medicamentos contra diferentes patologías. Uno de los grandes problemas en salud pública a nivel mundial en el contexto farmacológico es la producción de antibióticos y la ocurrencia de resistencia microbiana, además, cada vez resulta más complejo el uso de modelos animales por las restricciones bioéticas actuales, no obstante, es necesario usar modelos simples en los estudios preliminares que permitan evaluar las interacciones huésped-patógeno-antimicrobiano. Al validar que Caenorhabditis elegans es susceptible a varias bacterias y además tiene la capacidad de responder a estímulos ambientales con cambios observables en el comportamiento tras ser alimentado con diversas bacterias, resulta muy útil usarlo en este tipo de investigaciones ya que tiene una vida promedio corta y no cuenta con restricciones éticas para su uso. Por lo anterior, en este artículo se revisa la susceptibilidad que tiene C.elegans de infectarse con diferentes bacterias, además, ya que aún no se ha validado completamente como modelo para poner a prueba antimicrobianos se propone que este nematodo es útil como modelo In vivo para evaluar infecciones y tratamientos antibacterianos.

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