Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

Liliana Muñoz Molina; Juan Carlos Sabogal; Clara Arteaga; Rubistein Hernández; Ismena Mockus; Jairo Tovar

doi:10.22490/24629448.1054

Perinatal determination of Leptin in mothers and neonates with diagnosis of retard ofintra-uterine growth (RCIU)

Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

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Vol. 1 No. 1 (2003)

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Artículo Original

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Muñoz Molina, L., Sabogal, J. C., Arteaga, C., Hernández, R., Mockus, I., & Tovar, J. (2014). Perinatal determination of Leptin in mothers and neonates with diagnosis of retard ofintra-uterine growth (RCIU). NOVA, 1(1). https://doi.org/10.22490/24629448.1054

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https://doi.org/10.22490/24629448.1054

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NOVA by http://www.unicolmayor.edu.co/publicaciones/index.php/nova is distributed under a license creative commons non comertial-atribution-withoutderive 4.0 international.

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Liliana Muñoz Molina

Instituto Materno Infantil de Bogotá, Universidad Colegio Mayor de Cundinamarca.

Juan Carlos Sabogal

Universidad Nacional de Colombia

Clara Arteaga

Instituto Materno Infantil de Bogotá, Universidad Nacional de Colombia

Rubistein Hernández

Gimnasio Moderno

Ismena Mockus

Universidad Nacional de Colombia

Jairo Tovar

Pontificia Universidad Javeriana

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Leptin

Amniotic fluid

Apropiate for gestacional age

Maternal serum

Blood cord

Intrauteringrowth retarded

Recently it has been described that the leptin presents hormonal activity, acting on receivers and that it is involved in the regulation of the metabolic efficiency, spend energy and nutritious ingestion. Has been synthesized in the sincitiotrofoblastos and it is secreted inside the maternal circulation. The leptin has also been related in the deposit of fat. Since in the last trimester of the human pregnancy, in a characteristic way a relatively increased deposit of fat exists and that this leaves depletado evidently in the cases of RCIU, it is then probable that the leptin keeps relationship with the entity. The objective of this study was to investigate if differences exist among the leptin mensurations obtained in a group of healthy patients and with RCIU. The study was carried out in 12 patients with RCIU (cases) and 9 patients without RCIU (you control). For such a reason they took samples of maternal blood and blood cord and of amniotic liquid (THE). In the paired study (n=9) the leptin levels in children born with RCIU presented lower concentrations that the children control (p=0.05). The leptin concentrations in blood cord were correlated significantly with the weight of the neonate (p = 0.0002) and I weigh placentario (p = 0.048). It was not to significant correlation statistically of the leptin levels in maternal blood with the weight of the neonate and the placentario weight. The concentrations of amniotic liquid showed an inverse and statistically significant correlation with the weight neonatal (p = 0.035), but not with the placentario weight (p = 0.071). Inverse and statistically significant correlations were observed among: concentrations of maternal leptin and leptin in blood cord (p = 0.034); cord leptin with leptin in liquid amniotic (p = 0.011) and positive correlation between maternal leptin and leptin in the amniotic fluid (p = 0.01).

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DOI: http://dx.doi.org/10.22490/24629448.1054