Perinatal determination of Leptin in mothers and neonates with diagnosis of retard ofintra-uterine growth (RCIU)

Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

Open | Download
PDF (Spanish) FLIP HTML (Spanish)
How to Cite
Perinatal determination of Leptin in mothers and neonates with diagnosis of retard ofintra-uterine growth (RCIU). (2014). NOVA, 1(1). https://doi.org/10.22490/24629448.1054
doi

https://doi.org/10.22490/24629448.1054
Dimensions
PlumX
license

Licencia Creative Commons

NOVA by http://www.unicolmayor.edu.co/publicaciones/index.php/nova is distributed under a license creative commons non comertial-atribution-withoutderive 4.0 international.

Furthermore, the authors keep their property intellectual rights over the articles.

 

Liliana Muñoz Molina
Instituto Materno Infantil de Bogotá, Universidad Colegio Mayor de Cundinamarca.
    Juan Carlos Sabogal
    Universidad Nacional de Colombia
      Clara Arteaga
      Instituto Materno Infantil de Bogotá, Universidad Nacional de Colombia
        Rubistein Hernández
        Gimnasio Moderno
          Ismena Mockus
          Universidad Nacional de Colombia
            Jairo Tovar
            Pontificia Universidad Javeriana
              Show authors biography
              Recently it has been described that the leptin presents hormonal activity, acting on receivers and that it is involved in the regulation of the metabolic efficiency, spend energy and nutritious ingestion. Has been synthesized in the sincitiotrofoblastos and it is secreted inside the maternal circulation. The leptin has also been related in the deposit of fat. Since in the last trimester of the human pregnancy, in a characteristic way a relatively increased deposit of fat exists and that this leaves depletado evidently in the cases of RCIU, it is then probable that the leptin keeps relationship with the entity. The objective of this study was to investigate if differences exist among the leptin mensurations obtained in a group of healthy patients and with RCIU. The study was carried out in 12 patients with RCIU (cases) and 9 patients without RCIU (you control). For such a reason they took samples of maternal blood and blood cord and of amniotic liquid (THE). In the paired study (n=9) the leptin levels in children born with RCIU presented lower concentrations that the children control (p=0.05). The leptin concentrations in blood cord were correlated significantly with the weight of the neonate (p = 0.0002) and I weigh placentario (p = 0.048). It was not to significant correlation statistically of the leptin levels in maternal blood with the weight of the neonate and the placentario weight. The concentrations of amniotic liquid showed an inverse and statistically significant correlation with the weight neonatal (p = 0.035), but not with the placentario weight (p = 0.071). Inverse and statistically significant correlations were observed among: concentrations of maternal leptin and leptin in blood cord (p = 0.034); cord leptin with leptin in liquid amniotic (p = 0.011) and positive correlation between maternal leptin and leptin in the amniotic fluid (p = 0.01).

              Article visits 210 | PDF visits 106

              Downloads

              Download data is not yet available.
              1. Halaas J, Gajiwala K, MaffeiM, Cohen S, Chait B, RabinowitzD, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6.
              2. Green E, Maffe M, Braden V,Proenca R, Desilva U, Zhang Y, et al. The human obese (OB) gene: RNA expression patternand mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 1995;5:5-12.
              3. Gong Da-W, Bi Sh, Pratley R,Weintraub D. Genomic structure and promoter analysis of the human obese gene. The J BiolBiochem 1995;271:3971-4.
              4. Zhang F, et al. Crystal structure of the obese protein leptin- E100. Nature 1994;387:206-9.
              5. Schubring C, Kiess W, Englaro P, Rascher W, Dötsch J, Hanitsch S, et al. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J ClinEndocrinolMetab 1997;82:1480-3.
              6. Tartaglia L. The leptin receptor. J BiolChem 1997;272:6093 - 6.
              7. Fey H, Okano H, Li C, Lee G-H, Shako C, Darnell R, et al. Anatomical localization of alternatively spliced leptinreceptors (Ob-R) in mouse brain and other tissues. ProcNatlAcadSci USA 1997;94:7001-5.
              8. Schwarts M, Seeley R,Campfield L, Burn P, Baskin D. Identification of targets of leptin in rat hypothalamus. J ClinInvest 1996;98:1101-6.
              9. Chen H, Charlat O, TartagliaL, Woolf E, Wemg X, Ellis S, et al. Evidence that diabetes Gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/ db mice. Cell 1996;84:4915.
              10. Shimabukuro M, Kazunori K, Chen G, Wang M-Y, Trieu Y, Newgard C, et al. Direct antidiabetic effect of leptin through trygliceride depletion of tissues. Pro NatlAcadSci USA 1997;94:4637-41.
              11. Blum F, Englaro P, Hanitsch S,Juul A, Hertel N, Müller J, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testorene. J EndocrinolMetab1997;82:2904-10.
              12. Masuzaki H, OgawaY, Isse N. Human obese gene expression adiposity-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855-8.
              13. Hassink S, Sheslow D, Lancey E, Opentanova I, ConsidineR, Caro J. Serum leptin in children with obesity: relation to gender and development. Pediatrics 1996;98:201-3.
              14. Ahmed M, Ong K, Morrel D, Cox L, Drayer N, Perry L, et al. Longitudinal study of leptinconcentrations during puberty: sex differences and relationship to changes in body composition. J CliEndocrinoMetab 1999;84:899-905.
              15. Hoggard N, Hunter L, Duncan J, Williams L, Trayhurn P, Mercer J. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. ProcNatlAcadSci USA 1997;94:11073-8.
              16. Koistinen H, Koivisto V, Anderson S, Karonen S, Kontula K,Oksanen L, et al. Leptin concentration in cord blood correlates with intrauterine growth. J ClinEndocrinolMetab1997;82:3328-30.
              17. Harigaya A, Nagashima K, Nako Y, Akihiro M. Relationship between concentration of serum leptin and fetal growth. J ClinEndocrinolMetab 1997;82:3281-4.
              18. Tarquini B, Tarquini R, Perfetto F, Cornélissen G, Halberg F. Genetic and enviromental influences on human cord blood leptin concentration. Pediatrics 1999;103:998-1006.
              19. Matzuda J, Yokota I, Ilda M, Murakami T, Naito E, Ito M, et al. Serum leptin concentration in cord blood: relationshipto birth weight and gender. EndocrionlMetab 1997;82:1642-4.
              20. Mercer J, Moar K, Hoggard N. Localization of leptin receptor (Ob-R) messenger Ribonucleic Acid in the rodent hindbrain. Endocrinology 1998;139:29-34.
              21. Anshworth C, Hoggard N, Thomas L, Mercer J, Wallace J, Lea R. Placental leptin. Rev Reprod 2000;84:300-6.
              22. Lewandowski K, Horn R, O’Callaghan C, Dunlop D, Medley G, O’Hare P, et al. Free leptin, bound leptin, and soluble receptor in normal and diabetic pregnancies. J ClinEndocrinolMetab 1999;84:300-6.
              23. Hales C. Metabolic consequences of intrauterine growth retardation. Act Paediart 1997;423 Suppl:184-7.
              24. Tamura T, Robert M, Goldenberg R, Johnston K, Cliver S. Serum leptin concentrations during pregnancy and their relationship to fetal growth. ObstetGynecol 1998;91:389- 95.
              25. Linnemann K, Malek A, Sager R, Blum W, Schneider H, Fusch C. Leptin production and release in the Dually in vitro perfused human placenta. JEndocrinolMetab 2000;85:4298- 301.
              26. -------------------------------------------------------------------------------
              27. DOI: http://dx.doi.org/10.22490/24629448.1054
              Tutorials

              Autors:

              How send article?

              Evaluator pair

              How to evaluate an article?

              Information

              Keywords

              Google Scholar profile

              Is part of
               

              Current Issue

              Sistema OJS 3.4.0.5 - Metabiblioteca |