Regulation of the Bcl-2 protein family in cells infected with Chlamydia trachomatis

Regulación de la familia de proteínas BCL-2 en células infectadas con Chlamydia trachomatis

Published 2015-12-30

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Regulation of the Bcl-2 protein family in cells infected with Chlamydia trachomatis. (2015). NOVA, 13(24), 83-92. https://doi.org/10.22490/24629448.1718
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Adriana Paola Jutinico Shubach
Universidad Colegio Mayor de Cundinamarca
    Alejandra Mantilla Galindo
    Universidad Colegio Mayor de Cundinamarca
      Ruth Mélida Sánchez Mora
      Universidad Colegio Mayor de Cundinamarca
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        This article reviews the apoptosis inhibitory mechanisms used by Chlamydia trachomatis (Ct) aga-inst the Bcl-2 protein family to achieve its intracellular survival. Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular bacterium responsible for the infection of the most common sexually transmitted infection in the world; this organism is able to inhibit host cell apoptosis during development cycle, obtaining a safe survival refuge. When exposed to stimuli such as infection of the cell by a pathogen, the Bcl-2 protein family regulates cell apoptosis by releasing cytochromec from mitochondria to trigger programmed cell death (PCD). Ct uses various anti-apoptotic regulation mechanisms to survive within the host cell, some of them are: Protein secretion such as CPAF and CADD; the cleavage of Bid protein; the Bad kidnapping and in general the blocking of proteins that belong to the Bcl-2 family with BH3 domain, these affect the cell mitochondrial pathway causing Ct persistence, development, and replication within the host cell.

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        48. ==========================================
        49. DOI: http://dx.doi.org/10.22490/24629448.1718
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