Regulation of the Bcl-2 protein family in cells infected with Chlamydia trachomatis

Regulación de la familia de proteínas BCL-2 en células infectadas con Chlamydia trachomatis

Published 2015-12-30

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Vol. 13 No. 24 (2015)
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Jutinico Shubach, A. P., Mantilla Galindo, A., & Sánchez Mora, R. M. (2015). Regulation of the Bcl-2 protein family in cells infected with Chlamydia trachomatis. NOVA, 13(24), 83-92. https://doi.org/10.22490/24629448.1718
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https://doi.org/10.22490/24629448.1718
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Adriana Paola Jutinico Shubach
Universidad Colegio Mayor de Cundinamarca
    Alejandra Mantilla Galindo
    Universidad Colegio Mayor de Cundinamarca
      Ruth Mélida Sánchez Mora
      Universidad Colegio Mayor de Cundinamarca
        Show authors biography
        This article reviews the apoptosis inhibitory mechanisms used by Chlamydia trachomatis (Ct) aga-inst the Bcl-2 protein family to achieve its intracellular survival. Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular bacterium responsible for the infection of the most common sexually transmitted infection in the world; this organism is able to inhibit host cell apoptosis during development cycle, obtaining a safe survival refuge. When exposed to stimuli such as infection of the cell by a pathogen, the Bcl-2 protein family regulates cell apoptosis by releasing cytochromec from mitochondria to trigger programmed cell death (PCD). Ct uses various anti-apoptotic regulation mechanisms to survive within the host cell, some of them are: Protein secretion such as CPAF and CADD; the cleavage of Bid protein; the Bad kidnapping and in general the blocking of proteins that belong to the Bcl-2 family with BH3 domain, these affect the cell mitochondrial pathway causing Ct persistence, development, and replication within the host cell.

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        48. ==========================================
        49. DOI: http://dx.doi.org/10.22490/24629448.1718
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