Selecting a spray system for the formation of Eudragit ® S100 microparticles in a fluid bed

Selección de un sistema de atomización para la formación de micropartículas de Eudragit® S100 en lecho fluido

The development of microparticles in fluid bed is of high interest in the pharmaceutical, food and agriculture, as this type of formulation to control the release of active ingredients and their stability and functionality by the formation of small solid particles. The fluid bed equipment is commonly used in industry  to carry out the process and this can have two sets of spray drying: top spray and bottom spray.In thisstudy we evaluatedthe two setsofspraydrying towardstheformationofmicroparticlesofEudragit®S100. Experiments were conducted toadjustthecritical processfactorsandtheirlevelsusingamultilevelfactorialdesignand working inaGlattfluid bedbrandGmbHD-01277. Factorsevaluatedwerethe inlet temperature, thepressure insidethe chamber andtheflow rate. The coating materialconsisted ofamethacrylicacid polymerknownasEudragit® S100andcore325 meshpowderwasused.The system selected for the microencapsulation was top spray. The spray dryingconditions were set flow rate of4.12 mL/min (flow 8 rpm), inlet temperature of 80ºC and pressure inside the chamber 1 and 3 bars.The microparticles showed homogeneous shapes and sizes, less than 100 microns. The conditions set for the top spray system can be applied to the development of microencapsulation processes of different active ingredients using as polymer Eudragit® S100.

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32. DOI: http://dx.doi.org/10.22490/24629448.442