Mitochondria and cell death

Mitocondria y muerte celular

Recently the decisive role of mitochondria in the mechanisms of cell death has been defined in diverse models, where the permeability of the mitochondrial outer membrane and the important protein release of the intermembrane space of mitochondria are important characteristics that define this process. Specifically pro-apoptosis proteins such as Cytochrome c, Smac/devil among others, are released during early stages of the apoptosis process. The mechanisms by which these proteins are released depend presumably on the cell type and the nature of the stimulus. The activation of caspases (proteases of cysteine) during the early apoptosis seems to mainly be regulated by the family of the Bcl-2 proteins, whose main function is the control of the permeability of the mitochondrial membrane through the formation or regulation of pores, in particular the pore of mitochondrial transitional permeability. This revision intends to show a global vision of the role of mitochondria in the processes of cell death, in apoptosis and in some of the molecular mechanisms involved in its regulation.

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53. DOI: http://dx.doi.org/10.22490/24629448.409