Asociación de HSP60 de Chlamydia trachomatis y desarrollo de cáncer de ovario

Association between Hsp60 of Chlamydia trachomatis and ovarian cancer

Publicado 2017-11-02

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Vol. 15 Núm. 28 (2017)
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Jutinico Shubach, A. P., González Devia, J. L., & Sánchez Mora, R. M. (2017). Asociación de HSP60 de Chlamydia trachomatis y desarrollo de cáncer de ovario. REVISTA NOVA , 15(28), 57-68. https://doi.org/10.22490/24629448.2079
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https://doi.org/10.22490/24629448.2079
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Así mismo,  los autores mantienen sus derechos de propiedad intelectual sobre los artículos.  

Adriana Paola Jutinico Shubach
    Johanna Lizeth González Devia
      Ruth Mélida Sánchez Mora
        Mostrar biografía de los autores

        Las proteínas de choque térmico (HSP) son una familia de proteínas altamente conservadas cuya expresión se regula por la exposición a condiciones de estrés. Chlamydia trachomatis (CT) es una bacteria intracelular obligada de transmisión sexual causante de infección crónica y persistente que posibilita la expresión de proteínas tipo HSP, una de estas proteínas es la HSP60 Clamidial (cHSP60) que posee una homología del 50% con respecto a la proteína HSP60 humana. Esta
        revisión presenta estudios immunoepidemiológicos que han demostrado una asociación entre la respuesta inmune a cHSP60 y secuelas de la infección por CT generadas por la inflamación crónica, una de estas secuelas probablemente es el desarrollo de cáncer de ovario, patología que según la OMS es uno de los cánceres ginecológicos más letales y ocupa el quinto lugar en muertes por cáncer entre las mujeres. En esta revisión se discute como la presencia de la cHSP60 ocasiona una respuesta de anticuerpos prolongada como una fuente de estimulación antigénica e inflamación crónica, ocasionando reactividad cruzada que se asocia al desarrollo de cáncer de ovario.

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        1. REFERENCIAS
        2. Carvalho JP. Is Chlamydia-infected tubal fimbria the origin of ovarian cancer ? Med Hypotheses [Internet]. Elsevier Ltd; 2008;71(5):690–3. Disponible en: http://dx.doi.org/10.1016/j.mehy.2008.06.028
        3. Westbrook AM, Szakmary A, Schiestl RH. Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models. Mutat Res Mutat
        4. Res [Internet]. 2010 [cited 2017 Jul 19];705(1):40–59. Disponible en: http://www.sciencedirect.com.ezproxy.unal.edu.co/science/article/pii/S1383574210000244
        5. Wu J, Liu T, Rios Z, Mei Q, Lin X, Cao S. Heat Shock Proteins and Cancer. Trends Pharmacol Sci [Internet]. 2017 [cited 2017 Jul 19];38(3):226–56. Disponible en: http://www.sciencedirect.com.ezproxy.unal.edu.co/science/article/pii/S0165614716301675
        6. Alshamsan A, Khan S, Imran A, Aljuffali IA, Alsaleh K. Prediction of Chlamydia pneumoniae protein localization in host mitochondria and cytoplasm and possible involvements in lung cancer etiology: a computational approach. Saudi Pharm J [Internet]. 2017 May [cited 2017 Jul 19];
        7. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S1319016417301226
        8. Villagrana J, López M, Flores V, Haro MJ De, Escobedo M, Guerra F. Persistencia de Chlamydia trachomatis en el endometrio y líquido peritoneal de pacientes con infertilidad pero cultivo cervical negativo. Ginecol Obs MEx. 2013;81:23–8.
        9. Debattista J. Immunopathogenesis of chlamydia trachomatis infections in women. Fertil Steril. 2003 Jun;79(6):1273–87.
        10. Paavonen J, Karunakaran KP, Noguchi Y, Anttila T, Bloigu A, Dillner J, et al. Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer☆. Am J Obstet Gynecol. 2003 Nov;189(5):1287–92.
        11. Paavonen J. Sexually transmitted chlamydial infections and subfertility. 2004;1266:277–86.
        12. OMS. Epithelial ovarian cancer. Union for International Cancer Control. 2014.
        13. Güth U, Arndt V, Stadlmann S, Huang DJ, Singer G. Epidemiology in ovarian carcinoma: Lessons from autopsy. Gynecol Oncol. Elsevier Inc.; 2015;138(2):417–20.
        14. Rodríguez AO, Llacuachaqui M, Pardo GG, Royer R, Larson G, Weitzel JN, et al. BRCA1 and BRCA2 mutations among ovarian cancer patients from Colombia. Gynecol Oncol. Elsevier Inc.; 2012;124(2):236–43.
        15. González M, Barrera CA, Castillo JS. Cáncer epitelial avanzado de ovario en un grupo de pacientes colombianas. Rev Colomb Cancerol. 2014;17(4):142–8.
        16. American Cancer Society. What are the key statistics about ovarian cancer? 2015.
        17. Janson P, Sundfeldt K, Piontkewitz Y, Ivarsson K, Nilsson O, Enerback S, et al. E-Cadherin Expression in Human Epithelial Ovarian Cancer and Normal Ovary. 1997;280(February):
        18. –80.
        19. Strauss R, Li ZY, Liu Y, Beyer I, Persson J, Sova P, et al. Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One. 2011;6(1):1–20.
        20. Idahl A. Chlamydia trachomatis as a risk factor for infertility in women and men , and ovarian tumor development. 2009.
        21. Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR. The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis. 2008 Jan;2(9):e300.
        22. Cervantes E. Monografía: Infecciones causadas por Chlamydia trachomatis. medigraphic. 2009;52(1):18–22.
        23. Giles DK, Whittimore JD, LaRue RW, Raulston JE, Wyrick PB. Ultrastructural analysis of chlamydial antigen- containing vesicles everting from the Chlamydia trachomatis inclusion. Microbes Infect. 2006 May;8(6):1579–91.
        24. Idahl A, Lundin E, Jurstrand M, Kumlin U, Elgh F, Ohlson N, et al. Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors. 2011;2011.
        25. Balakrishnan A, Wang L, Li X, Ohman-Strickland P, Malatesta P, Fan H. Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide
        26. deformylase inhibitor. Microbiol Res. 2009 Jan;164(3):338–46.
        27. de Waaij DJ, Dubbink JH, Peters RPH, Ouburg S, Morré S a. Comparison of GMT presto assay and Roche cobas® 4800 CT/NG assay for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in dry swabs. J Microbiol Methods. Elsevier B.V.; 2015;118:70–4.
        28. Schautteet K, De Clercq E, Jönsson Y, Lagae S, Chiers K, Cox E, et al. Protection of pigs against genital Chlamydia trachomatis challenge by parenteral or mucosal DNA immunization.
        29. Vaccine. Elsevier Ltd; 2012 Apr;30(18):2869–81.
        30. Broadbent A, Horner P, Wills G, Ling A, Carzaniga R, McClure M. HIV-1 does not significantly influence Chlamydia trachomatis serovar L2 replication in vitro. Microbes Infect. Elsevier Masson SAS; 2011 Jun;13(6):575–84.
        31. Linhares IM, Witkin SS. Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract. 2010;467–73.
        32. Sävykoski T. Chlamydia pneumoniae infection, inflammation and heat shock protein 60 immunity in asthma and coronary heart disease [Internet]. Oulun yliopisto; 2003 [cited 2017 Jul 22]. Disponible en: http://jultika.oulu.fi/Record/isbn951-42-6985-3
        33. Charley M. Chlamydial Life Cycle And Persistence - Chlamydia Pneumoniae [Internet]. [cited 2017 Jul 22]. Disponible en: https://www.clicktocurecancer.info/chlamydia-
        34. pneumoniae/chlamydial-life-cycle-and-persistence.html
        35. Habich C, Kempe K, Gomez FJ, Lillicrap M, Gaston H, Zee R Van Der, et al. Heat shock protein 60 : Identification of specific epitopes for binding to primary macrophages. 2006;580:115–20.
        36. Bozaykut P, Ozer NK, Karademir B. Regulation of protein turnover by heat shock proteins. Free Radic Biol Med. Elsevier; 2014 Dec;77:195–209.
        37. Bodzek P, Partyka R, Damasiewicz-Bodzek A. Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer. J Ovarian Res. 2014;7(1):30.
        38. Faried A, Faried L, Capello F, Conway de Macario E, Macario AJ. HSPD1 (Heat Shock 60kDa Protein 1) [Internet]. Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2014 [cited 2017 Jul 20]. Disponible en: http://atlasgeneticsoncology.org//Genes/HSPD1ID40888ch2q33.html
        39. Kumar Singh M, Janardhan Reddy PV, Sreedhar a. S, Tiwari PK. Molecular characterization and expression analysis of hsp60 gene homologue of sheep blowfly, Lucilia cuprina. J Therm Biol. Elsevier; 2015;52:24–37.
        40. Magro CM, Crowson AN, Peeling R. Vasculitis as the Basis of Cutaneous Lesions in Reiter â€TM s Disease. 60(2).
        41. Ricci C, Ortore MG, Vilasi S, Carrotta R, Mangione MR, Bulone D, et al. Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins. Biophys Chem. Elsevier B.V.; 2016;208:68–75.
        42. Cappello F, De MacArio EC, Zummo G, MacArio AJL. Immunohistochemistry of human Hsp60 in health and disease: From autoimmunity to cancer. Methods Mol Biol [Internet]. 2011 [cited 2017 Jul 20];787:245–54. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/21898240
        43. Campanella C, Bucchieri F, Merendino AM, Fucarino A, Burgio G, Corona DF V., et al. The Odyssey of Hsp60 from Tumor Cells to Other Destinations Includes Plasma Membrane-Associated Stages and Golgi and Exosomal Protein- Trafficking Modalities. Metze K, editor. PLoS One [Internet].
        44. Public Library of Science; 2012 Jul 25 [cited 2017 Jul 22];7(7):e42008. Disponible en: http://dx.plos.org/10.1371/journal.pone.0042008
        45. Tomasello G, Rodolico V, Zerilli M, Martorana A, Bucchieri F, Pitruzzella A, et al. Changes in Immunohistochemical Levels and Subcellular Localization After Therapy and Correlation
        46. and Colocalization With CD68 Suggest a Pathogenetic Role of Hsp60 in Ulcerative Colitis. Appl Immunohistochem Mol Morphol [Internet]. 2011 Dec [cited 2017 Jul 29];19(6):552–61. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/21441812
        47. Money DM, Hawes SE, Eschenbach D a., Peeling RW, Brunham R, Wölner-Hanssen P, et al. Antibodies to the chlamydial 60 kd heat-shock protein are associated with laparoscopically
        48. confirmed perihepatitis. Am J Obstet Gynecol. 1997 Apr;176(4):870–7.
        49. Ge C, Whittum-hudson JA, Schumacher HR, Hudson AP. Differential expression of three Chlamydia trachomatis hsp60-encoding genes in active vs . persistent infections. 2004;36:35–9.
        50. Karunakaran KP, Noguchi Y, Read TD, Cherkasov a., Kwee J, Shen C, et al. Molecular Analysis of the Multiple GroEL Proteins of Chlamydiae. J Bacteriol. 2003 Mar;185(6):1958–66.
        51. Cortiñas P, Muñoz G, Loureiro C, Pujol F. Follicular Fluid Antibodies to Chlamydia trachomatis and Human Heat Shock Protein-60 kDa and Infertility in Women. 2004;35:121–5.
        52. Cappello F, Caramori G, Campanella C, Vicari C, Gnemmi I, Zanini A, et al. Convergent Sets of Data from In Vivo and In Vitro Methods Point to an Active Role of Hsp60 in Chronic Obstructive Pulmonary Disease Pathogenesis. Chu HW, editor. PLoS One [Internet]. 2011 Nov 28 [cited 2017
        53. Jul 22];6(11):e28200. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/22140545
        54. Cappello F, Marino Gammazza A, Zummo L, Conway de Macario E, Macario AJL. Hsp60 and AChR cross-reactivity in myasthenia gravis: An update. J Neurol Sci [Internet]. 2010 May 15 [cited 2017 Jul 22];292(1–2):117–8. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/20236663
        55. Marino Gammazza A, Bucchieri F, Grimaldi LME, Benigno A, Conway de Macario E, Macario AJL, et al. The Molecular Anatomy of Human Hsp60 and its Similarity with that of Bacterial Orthologs and Acetylcholine Receptor Reveal a Potential Pathogenetic Role of Anti-Chaperonin Immunity in
        56. Myasthenia Gravis. Cell Mol Neurobiol [Internet]. 2012 Aug 19 [cited 2017 Jul 22];32(6):943–7. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/22258649
        57. Marino Gammazza A, Rizzo M, Citarrella R, Rappa F, Campanella C, Bucchieri F, et al. Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto’s thyroiditis. Cell Stress Chaperones [Internet]. 2014 May 22 [cited 2017 Jul 22];19(3):343–53. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/24057177
        58. Jones DB, Coulson AFW, Duff GW. Sequence homolo gies between hsp60 and autoantigens. Immunol Today [Internet]. 1993 Jan [cited 2017 Jul 22];14(3):115–8. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/8466626
        59. Ngan F, Gupta M, Luke S. Methods for Detecting Genetic Abnormalities in Ovarian Carcinoma Using Fluorescence in situ Hybridization and Immunohistochemistry. 2006;
        60. Ness RB, Goodman MT, Shen C, Brunham RC. Serologic Evidence of Past Infection in Relation to Ovarian Cancer. 2003;187:1147–52.
        61. Claman P, Honey L, Peeling RW, Jessamine P, Toye B. The presence of serum antibody to the chlamydial heat shock protein (CHSP60) as a diagnostic test for tubal factor infertility. Fertil Steril. 1997 Mar;67(3):501–4.
        62. Liuba P, Pesonen E, Paakkari I, Forelid A, Sandstrom S. ABSTRACTS - Hypertension , Vascular Disease , and Prevention 2 7 7 A Chlamydia Pneumoniae Resulted In Plaque Pormation Acute Chlamydia Pneumoniae Infection Causes Diffuse Adenosine Deaminase Inhibition Attenuates the. :60.
        63. Daponte A, Pournaras S, Deligeoroglou E, Skentou H, Messinis IE. Serum interleukin-1β, interleukin-8 and anti- heat shock 60 Chlamydia trachomatis antibodies as markers of ectopic pregnancy. J Reprod Immunol. Elsevier Ireland Ltd; 2012 Mar;93(2):102–8.
        64. Carvalho JP, Carvalho FM. Is Chlamydia-infected tubal fimbria the origin of ovarian cancer? Med Hypotheses. Elsevier Ltd; 2008 Nov;71(5):690–3.
        65. Hjelholt A, Christiansen G, Johannesson TG, Ingerslev HJ, Birkelund S. Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 (HSP60) but not human HSP60. Hum Reprod [Internet]. 2011 Aug 1 [cited 2017 Jul 22];26(8):2069–76. Disponible en: https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/der167
        66. López-hurtado M, Guerra-infante FM. P apel de los anticuerpos en el desarrollo de la infección por Chlamydia trachomatis y su utilidad en el diagnóstico. 2002;16(3):140–50.
        67. Forsbach-Birk V, Simnacher U, Pfrepper K-I, Soutschek E, Kiselev a O, Lampe MF, et al. Identification and evaluation of a combination of chlamydial antigens to support the diagnosis
        68. of severe and invasive Chlamydia trachomatis infections. Clin Microbiol Infect. European Society of Clinical Infectious Diseases; 2010 Aug;16(8):1237–44.
        69. Rodríguez Rojas Fredy Alberto, Barreto Ordoñez Paula Steffany, Sánchez Mora Ruth Mélida. Detección de Chlamydia trachomatis en hombres que tienen sexo con hombres en Bogotá: un estudio piloto. Nova [Internet]. 2016 Dec [cited 2017 Aug 02] ; 14( 26 ): 17-27. Available from:
        70. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1794-4702016000200002&lng=en.
        71. Mantilla Alejandra, Martínez Jhonathan, Ramírez Mateo Santiago, Olave Luis Felipe, Jutinico Shubach Adriana Paola, Gómez María C et al . Determinación de IgG contra Chlamidya trachomatis en mujeres con artritis de la Ciudad de Bogotá D.C. Un estudio piloto. Nova [Internet]. 2016 June [cited 2017 Aug 02] ; 14( 25 ): 27-34. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1794-24702016000100003&lng=en.
        72. Páez, L. C. C., et al. Comparación del cultivo celular de HeLa y HEp-2: Perspectivas de estudios con Chlamydia trachomatis. 2015; Nova 13(23).
        73. DOI: http://dx.doi.org/10.22490/24629448.2079
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