Perfil de resistencia a antibióticos en bacterias que presentan la enzima NDM-1 y sus mecanismos asociados: una revisión sistemática
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Castañeda, J., Gómez, K., Corrales, L., & Cortés, S. (2017). Perfil de resistencia a antibióticos en bacterias que presentan la enzima NDM-1 y sus mecanismos asociados: una revisión sistemática. NOVA, 14(25), 95-111. https://doi.org/10.22490/24629448.1733
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Jeimmy Castañeda
Karen Gómez
Lucía Corrales
Sebastián Cortés
Resumen
En 2008 se reportó la enzima NDM-1 que genera resistencia a carbapenémicos. Para determinar el perfil de resistencia que presentan las bacterias frente a esta enzima se adelantó una revisión sistemática. La búsqueda de artículos se realizó en diferentes bases de datos y para su selección se consideraron criterios de inclusión y exclusión obteniendo un total de 154 artículos. Se identificaron 617 casos, presentados en trece géneros bacterianos, que codifican para los cuatro mecanismos de resistencia, principalmente a betalactámicos y aminoglucósidos. Cuando se presenta la enzima, la posibilidad que haya genes asociados para la producción de resistencias es alta, generando así que se presenten mecanismos que evitan la acción del antibiótico haciendo difícil implementar un tratamiento efectivo.
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.
Así mismo, los autores mantienen sus derechos de propiedad intelectual sobre los artículos.
Referencias
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DOI: http://dx.doi.org/10.22490/24629448.1733
2. Grundmann H. Towards a global antibiotic resistance surveillance system: a primer for a roadmap. Ups J Med Sci. 2014;119(2):87–95.
3. Organización Mundial de la Salud. Antimicrobial Resistance Global Report on Surveillance 2014. [Internet] Disponible en: http://www.who.int/drugresistance/documents/AMR_report_ Web_slide_set.pdf?ua=1
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6. Nordmann P, Poirel L, Carrër A, Toleman M a., Walsh TR. How to detect NDM-1 producers. J Clin Microbiol. 2011;49(2):718–21.
7. Arce-gil Z, Flores-clavo R. Deteccion del gen CTX-M en cepas de Escherichia coli productoras de betalactamasas de espectro extendido procedentes del hospital regional de lambayeque; Chiclayo-Perú: Noviembre 2012-Julio 2013. 2013;6(4):13–6.
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9. Mosquito S, Ruiz J, Ochoa TJ. MECANISMOS MOLECULARES DE RESISTENCIA ANTIBIÓTICA EN Escherichia coli ASOCIADAS A DIARREA. Rev Peru Med Exp Salud Publica. 2011;28(4):9–11.
10. Jacoby G a. AmpC β-Lactamases. Clin Microbiol Rev. 2009;22(1):161–82.
11. Verdet C, Benzerara Y, Gautier V, Adam O, Ould-Hocine Z, Arlet G. Emergence of DHA-1-producing Klebsiella spp. in the Parisian region: Genetic organization of the ampC and ampR genes originating from Morganella morganii. Antimicrob Agents Chemother. 2006;50(2):607–17.
12. Yao Q, Zeng Z, Hou J, Deng Y, He L, Tian W, et al. Dissemination of the rmtB gene carried on IncF and IncN plasmids among Enterobacteriaceae in a pig farm and its environment. J Antimicrob Chemother. 2011;66(11):2475–9.
13. Hou J, Yang X, Zeng Z, Lv L, Yang T, Lin D, et al. Detection of the plasmid-encoded fosfomycin resistance gene fosA3 in Escherichia coli of food-animal origin. J Antimicrob Chemother. 2013;68(4):766–70.
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15. Kang M, Besser TE, Call DR. Variability in the Region Downstream of the bla CMY-2 β -Lactamase Gene in Escherichia coli and Salmonella enterica Plasmids. 2006;50(4):1590–3.
16. Ma L, Lin CJ, Chen JH, Fung CP, Chang FY, Lai YK, et al. Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum B-lactamases. Antimicrob Agents Chemother. 2009;53(1):104–11.
17. Aminoglucósidos RA, Cepas EN, M LM, B GP, Ruiz - Parra AI, C YC, et al. DETERMINACIÓN DEL GEN aac(6´)aph(2´´) asociado con resistencia a aminoglucósidos en cepas de staphylococcus coagulasa negativa en una unidad neonatal en Bogotá. 2009;55:326–33.
18. Lidia Yolanda Fuchs, M.C. PD. LC. Mecanismos moleculares de la resistencia bacteriana. Salud Publica Mex. 1994;36(4):428–38.
19. Organizacion Panamericana de la salud organizacion mundial de la salud. Actualización Epidemiológica, carbapenemasas tipo New Delhi metalobetalactamasas (NDM). 2014: 1–3.
20. Shallcross LJ, Davies SC. The World Health Assembly resolution on antimicrobial resistance. J Antimicrob Chemother. 2014;69(11):2883–5.
21. Qin S, Fu Y, Zhang Q, Qi H, Wen JG, Xu H, et al. High incidence and endemic spread of NDM-1 positive Enterobacteriaceae in Henan province, China. Antimicrob Agents Chemother. 2014;58(8):4275–82.
22. Ageevets V a., Partina I V., Lisitsyna ES, Ilina EN, Lobzin Y V., Shlyapnikov S a., et al. Emergence of carbapenemaseproducing Gram-negative bacteria in Saint Petersburg, Russia. Int J Antimicrob Agents. Elsevier B.V. 2014;44(2):152–5.
23. Yong D, Toleman M a., Giske CG, Cho HS, Sundman K, Lee K, et al. Characterization of a new metallo-??-lactamase gene, bla NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009;53(12):5046–54.
24. Jones LS, Toleman M a., Weeks JL, Howe R a., Walsh TR, Kumarasamy KK. Plasmid carriage of blaNDM-1in clinical Acinetobacter baumannii isolates from India. Antimicrob Agents Chemother. 2014;58(7):4211–3.
25. Collantes F. India: colonialismo, pobreza y estrategias de desarrollo. 1–34 [Internet]. Disponible en http://www.unizar. es/departamentos/estructura_economica/personal/collantf/ documents/India-Texto.pdf
26. Gaibani P, Ambretti S, Berlingeri a., Cordovana M, Farruggia P, Panico M, et al. Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro Surveill Bull Eur sur les Mal Transm = Eur Commun Dis Bull. 2011;16(47):2002.
27. Teo J, Ngan G, Balm M, Jureen R, Krishnan P, Lin R. Molecular characterization of NDM-1 producing Enterobacteriaceae isolates in Singapore hospitals. West Pacific Surveill Response. 2012;3(1):1–1.
28. Mulvey MR, Grant JM, Plewes K, Roscoe D, Boyd D a. New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada. Emerg Infect Dis. 2011;17(1):103–6.
29. Mochon a. B, Garner OB, Hindler J a., Krogstad P, Ward KW,
Lewinski M a., et al. New Delhi metallo-β-lactamase (NDM1)-producing klebsiella pneumoniae: Case report and laboratory detection strategies. J Clin Microbiol. 2011;49(4):1667–70.
30. Carvalho-Assef APDA, Pereira PS, Albano RM, Berião GC, Chagas TPG, Timm LN, et al. Isolation of NDM-producing providencia rettgeri in brazil. J Antimicrob Chemother. 2013;68(12):2956–7.
31. Rozales FP, Ribeiro VB, Magagnin CM, Pagano M, Lutz L, Falci DR, et al. Emergence of NDM-1-producing Enterobacteriaceae in Porto Alegre, Brazil. Int J Infect Dis. 2014;25:79–81.
32. Carvalho-Assef APDA, Pereira PS, Albano RM, Berião GC, Tavares CP, Chagas TPG, et al. Detection of NDM-1-, CTX-M-15-, and qnrB4-producing enterobacter hormaechei isolates in Brazil. Antimicrob Agents Chemother. 2014;58(4):2475–6.
33. Barguigua A, Zerouali K, Katfy K, El Otmani F, Timinouni
M, Elmdaghri N. Occurrence of OXA-48 and NDM1 carbapenemase-producing Klebsiella pneumoniae in a Moroccan university hospital in Casablanca, Morocco. Infect Genet Evol. 2015;31:142–8. 34.
34. Escobar Pérez JA, Olarte Escobar NM, Castro-Cardozo B, Valderrama Márquez IA, Garzón Aguilar MI, De La Barrera LM, et al. Outbreak of NDM-1-producing Klebsiella pneumoniae in a neonatal unit in Colombia. Antimicrob Agents Chemother. 2013;57(4):1957–60.
35. Instituto Nacional de la Salud. Circular 1000 - 0057. [Internet]. 2012. Disponible en: http://www.ins.gov.co/ normatividad/Normatividad/circular 0057 de 2012.PDF
36. IQEN. Circulación de Carbapenemasas tipo New Delhi Metalo-β- lactamasa (NDM), Colombia, 2011 a 2013.
2013;18(11):111–20. Disponible en: http://www.ins.gov. co:81/iqen/IQUEN/IQEN vol 18 2013 num 11.pdf
37. ANTIMICROBIAL RESISTANCE Global Report on
Surveillance 2014.Organizacion Mundial de la Salud. 2014.
38. Organización Mundial de la Salud. Hojas de información microbiológica. Guías para la Calid del agua potable [Internet]. 2008;191–241.Disponible en: http://www.who. int/water_sanitation_health/dwq/gdwq3_es_11.pdf
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DOI: http://dx.doi.org/10.22490/24629448.1733
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