Estrategias diagnósticas utilizadas para detectar deficiencias de hierro subclínicas y asociadas a enfermedades crónicas

Diagnostic strategies for detecting subclinical iron deficiencies and associated to chronic diseases

Publicado 2005-12-31

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Vol. 3 Núm. 4 (2005)
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Coy, L. S., Castillo, M., Mora, A. I., Oliveros, A. L., & Vélez, Z. (2005). Estrategias diagnósticas utilizadas para detectar deficiencias de hierro subclínicas y asociadas a enfermedades crónicas. REVISTA NOVA , 3(4). https://doi.org/10.22490/24629448.337
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https://doi.org/10.22490/24629448.337
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

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Luz Stella Coy
Universidad Colegio Mayor de Cundinamarca
    Martha Castillo
    Universidad Colegio Mayor de Cundinamarca
      Ana Isabel Mora
      Universidad Colegio Mayor de Cundinamarca
        Ana Lucía Oliveros
        Universidad Colegio Mayor de Cundinamarca
          Zulay Vélez
          Universidad Colegio Mayor de Cundinamarca
            Mostrar biografía de los autores

            La homeostasis y las variaciones fisiológicas horarias en el metabolismo del hierro se constituyen en verdaderos desafíos para los expertos, quienes intentan diseñar pruebas altamente sensibles y específicas que cuantifiquen los niveles circulantes y de depósito de este elemento, su repercusión en la eritropoyesis, cuantificación de las proteínas, transportadores y receptores involucrados en el proceso, a fin de descartar la presencia de estados carenciales. Las deficiencias de hierro pasan por tres fases; las dos primeras son las más difíciles de identificar porque son subclínicas, más aún, cuando pueden cursar simultáneamente con enfermedades crónicas inflamatorias, infecciosas y neoplásicas que de por sí son anemizantes. En este trabajo se revisarán las principales pruebas de laboratorio utilizadas para la identificación de deficiencias de hierro, sensibilidad, especificidad, ventajas y limitaciones para su uso.

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            1. Instituto Nacional de Salud de Colombia. Deficiencia de hierro, vitamina A y prevalencia de parasitismo intestinal en la población infantil y anemia nutricional en mujeres en edad fértil. Santa Fe de Bogotá, Ministerio Nacional de Salud; 1996.
            2. Agudelo G, Cardona O, Posada M, Montoya M, Ocampo M, Marín C, et al. Prevalencia de anemia ferropénica en escolares y adolescentes, Medellín, Colombia, 1999. Pan Am J Public Health 2003; 13(6):376-86.
            3. De Maeyer E, Adiels-Tegman M. The prevalence of anaemia in the world. World Health Stat Q 1985; 38:302-16.
            4. Dallman PR, Yip R. Changing characteristics of childhood anemia (especial article). J Pediatr 1989; 114:161.
            5. Cook JD, Skikne BS. Estimates of iron sufficiency in the US population. Blood 1986; 68:726-31.
            6. Bothwell TH, Charlton RW. A general approach of the problems of iron deficiency and iron overload in the population at large. Seminars in Hematology 1982; 19:54.
            7. Birgegard G, Hellgran R, Killander A, Stromberg A, Venge P, Wide L. Serum ferritin during infection. Scand J Haematol 1978; 21: 333-40.
            8. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992; 119: 385-90.
            9. Noe G, Augustin J, Hausdolf S, Rich IN, Kubaneck B. Serum erythropoietin and transferrin receptor levels in patients with rheumatoid arthritis. Clin Exp Rheumatoid1995; 13:445-51.
            10. Ali M, Luxton AW, Walker W. Serum ferritin concentration and bone marrow iron stores: a prospective study. Scan Med Assoc J 1978; 118: 945-46.
            11. Pigeon C. A new mouse liver specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol chem 2001; 276:7806-10.
            12. Schaible U, Collins H, Priem F, Kaufman S. Correction of the iron overload defect in beta-2-microglobulin Knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. J Exp Med 2002; 196:1507-13.
            13. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 1974; 290:1213-6.
            14. Cook JD, Lipschitz DA, Miles LE, Finch CA. Serum ferritin as measure of iron stores in normal subjets. Am J Clin Nutr 1974; 27:681-7.
            15. Mast A, Blinder M, Gronowsky A, Shumley C, Scott M. Clinical Utility of the Soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 1998; 44:45-51.
            16. United Nations Children.s Fund, United Nations University, World Health Organization. Iron deficiency anaemia
            17. assessment, prevention and control. A guide for programme managers. Geneva: WHO; 2001.
            18. Punnonen K, Irjala K, Rajamäki A. Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of
            19. Iron Deficiency. Blood 1997; 89(3): 1052-7.
            20. Lee E, Oh EJ, Park YJ, Lee H, Kim B. Soluble Transferrin Receptor (sTfR), Ferritin and sTfR/log Ferritin Index in
            21. Anemic Patients with Nonhematologic Malignancy and Chronic Inflammation. Clin Chem 2002; 48:1118-21.
            22. Loria A, Hershko C, Konijin A. Serum ferritin in an elderly population. J Gerontol 1979; 34:521-4.
            23. Casale G, Bonora C, Migliavacca A, Zurita I, de Nicola P. Serum ferritin and aging. Age Ageing 1981; 10:119-22.
            24. Holyoake TL, Stott Dj, McKay PJ, Hendry A, McDonald JB, Lucie NP. Use of plasma ferritin concentration to diagnose iron deficiency in elderly patients. J Clin Pathol 1993; 46:857-60.
            25. Joosten E, Ghesquiere B, Linthoudt H. Upper and lower gastrointestinal evaluation of elderly inpatients who are iron deficient. Am J Med 1999; 107:24-9.
            26. Ruivard M, Boursiac M, Mareynat G. Diagnosis of iron deficiency: evaluation of the .soluble transferrin receptor/
            27. transferrin. ratio. Rev Med Interne 2000; 21:837-43.
            28. Worwood M, Thorpe SJ, Health A, Flowers C, Cook J. Stable lyophilized reagents for the serum ferritin assay. Clin
            29. Haematol 1991; 13:297-305.
            30. Flowers CH, Cook JD. Assessment of a Whole blood Spot method for the measurement of ferritin and transferrin receptor. FASEB J 1996; 10:A243.
            31. Ahluwalia N, Bulux J, Solomons N, Romero-Abal ME, Hernández M, Boy E. Ferritin concentrations in dried serum spots prepared by Standard compared whith simplified approaches: a validation study in Guatemala City. Am J. Clin
            32. Nutr 2005; 81: 1366-71.
            33. Ahluwalia N, Silva A, Atukorala S, Weaver V, Molls R. Ferritin concentrations in dried serum spots from capillary and venous blood in children in Sri Lanka: a validation study. Am J Clin Nutr 2002; 75: 289-94.
            34. Ahluwalia N, Lönnerdal B, Lorenz S, Allen L. Spot ferritin assay for serum simples dried on filter paper. Am J Clin Nutr 1998; 67:88-92.
            35. Flowers CH, Cook JD. Dried Plasma Spot Measurements of Ferritin and Transferrin Receptor for Assessing Iron Status. Clin Chem 1999; 45:1826-32.
            36. Haddad E, Moura I C, Arcos-Fajardo M, Macher MA, Baudouin V, Alberti O, et al. Enhanced expression of the CD71 mesangial Ig A1 receptor in Berger disease and Henoch- Schonlein nephritis: association between CD71 expressionand Ig A deposits. J Am Soc Nephrol 2003; 14 (2): 327-37.
            37. Brekelmans P, Van Soest P, Voerman J, Platenburg PP, Leenen PJ, Van Ewijk W. Transferrin receptor expression as a marker of immature cycling thymocytes in the mouse. Cell Inmunol 1994; 159 (2): 331-9.
            38. Vannelli BG, Orlando C, Barni T, Natali A, Serio M, Balboni GC. Immunostaining of transferrin and transferrin receptor in human seminiferous tubules. Fertil Steril 1986; 45 (4): 536-41.
            39. Zalata A, Hafez T, Schoonjans F, Comhaire F. The possible meanning of transferrin and its soluble receptors in seminal plasma as markers of the seminiferous epithelium. Hum Reprod 1996; 11 (4): 761-4.
            40. Moos T. Brain iron homeostasis. Dan Med Bull 2002; 49 (4): 279-301.
            41. Hayes GR, Williams A, Costello CE, Enris CA, Lucas JJ. The critical glycosylation site of human transferring receptor contains a high-mannose oligosaccharide. Glycobiology 1995; 5 (2): 227-32.
            42. Gross S, Helm K, Gruntmeir JJ, Stillman WS, Pyatt DW, Irons RD. Characterizacion and phenotypic analysis of
            43. differenciacing CD34+ human bone marrow cells in liquid culture. Eur J Haematol 1997; 59 (5); 318-26.
            44. Taylor A, Hogan BLM, Watt FM. Biosynthesis of EGF receptor,
            45. transferrin receptor and collagen by cultured human
            46. Keratinocytes and the effect of retinoid acid. Exp Cell Res
            47. ; 159: 47-54.
            48. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD. Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 1990; 265(31): 19077-81.
            49. Kato J, Kobune M, Kohgo Y, Fujikawa R, Takimoto R, Torimoto Y. Ratio of Transferrin (Tf) to Tf-Receptor
            50. Complex in Circulation Differs Depending on Tf Iron Saturation. Clin Chem 2002; 48:181-3.
            51. Ahn J, Johnstone RM. Origin of a soluble truncated transferrin receptor. Blood 1993; 81: 2442-5.
            52. Baynes RD, Skikne BS, Cook JD. Circulating transferring receptors and assessment of iron status. J Nutr Biochem 1994; 5:322.
            53. Hoffbrand V, Lewis MS, Tuddenham E. Postgraduate Haematology. 4th en. London: Butterworth Heinemann
            54. International Editions, 1999, p 23-46.
            55. Kohgo Y, Niitsu Y, Kondo H. Serum transferrin receptor as a new index of erithropoiesis. Blood 1987; 70: 1955-8.
            56. Flowers CH, Skikne BS, Covell AM, Cook JD. The clinical measurement of serum transferrin receptor. J Lab Clin Med 1989; 114:368-77.
            57. Skikne B, Flowers C, Cook J. Serum transferrin receptor: A quantitative measure of tissue iron deficiency. Blood 1990; 75:1870-6.
            58. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992; 19: 385-90.
            59. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 1990; 75: 102-7.
            60. Khumalo H, Gomo Z, Moyo V., Gordeuk V, Saungweme T, Rouault T, et al. Serum transferrin receptors are decreased in the presence of iron overload. Clin Chem 1998; 44:40-4.
            61. Beguin Y, Clemens GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and fuctional classification of anemia based on measurement of serum transferrin receptor and erythropoietin. Blood 1993; 81:1067-76.
            62. Carmel R, Skikne BS. Serum transferrin receptor in the megaloblastic anemia of cobalamin deficiency. Eur J Haematol 1992; 49:246-50.
            63. Vikstedt R, Lode P, Takala T, Irjala K, Peltola O, Pettersson K, et al. Rapid One-Step Immunofluorometric Assay for
            64. Measuring Soluble Transferrin Receptor in Whole Blood. Clin Chem 2004; 50(10): 1831-3.
            65. Zeng L, Sharieff W. Comments on Use of Combined Measures from Capillary Blood to Assess Iron Deficiency in Rural Kenyan Children. J Nutr 2004; 134:1844-5.
            66. Rimon E, Levy S, Sapir A, Gelzer G, Peled R, Ergas D, et al. Diagnosis of iron deficiency anemia in the elderly by transferrin receptor . ferritin index. Arch Intern Med 2002; 162: 445-9.
            67. Looker AC, Loyevsky M, Gordeuk VR. Increased Serum Transferrin Saturation Is Associated with Lower Serum Transferrin Receptor Concentration. Clin Chem 1999; 45: 2191-9.
            68. Dowlati A, R´Zik S, Fillet G, Beguin Y. Anaemia of Lung cancer is due to impaired erythroid marrow response to
            69. erythropoietin stimulation as well as relative inadequacy of erythropoietin production. Br J Haematol 1997; 97:297-9.
            70. Suominen P, Punnonoen K, Rajamäki A. Serum transferrin receptor and transferrin receptor.ferritin. Index Identify
            71. Healthy Subjects with subclinical iron deficits. Blood 1998; 92 (8): 2934-39.
            72. Fairbanks VF, Beutler E. Iron deficiency. In: Beutler E, Lichtman MA, Coller BS, et al, edts. Williams Hematology.
            73. th ed. New York, NY: Mc Graw Hill Medical Publishing Division; 2001:447-70.
            74. ----------------------------------------------------------------------------
            75. DOI: http://dx.doi.org/10.22490/24629448.337
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