Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración

Role of mitochondrial-derived peptide humanin as a therapeutic target in cancer and neurodegeneration

Publicado 2019-10-23

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Vol. 17 Núm. 32 (2019): Julio - Diciembre
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Asad, A. S., Florencia Zuccato, C., Nicola Candia, A. J., Florencia Gottardo, M., Moreno Ayala, M. A., Theas, M. S., Seilicovich, A., & Candolfi, M. (2019). Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración. REVISTA NOVA , 17(32), 9-24. https://doi.org/10.25058/24629448.3630
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https://doi.org/10.25058/24629448.3630
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Así mismo,  los autores mantienen sus derechos de propiedad intelectual sobre los artículos.  

Antonela Sofía Asad
    https://orcid.org/0000-0002-1234-7250

    Camila Florencia Zuccato
      https://orcid.org/0000-0002-3170-7397

      Alejandro Javier Nicola Candia
        María Florencia Gottardo
          https://orcid.org/0000-0001-6599-5094

          Mariela Alejandra Moreno Ayala
            https://orcid.org/0000-0002-7612-6852

            María Susana Theas
              https://orcid.org/0000-0002-8971-9833

              Adriana Seilicovich
                https://orcid.org/0000-0002-2949-2921

                Marianela Candolfi
                  https://orcid.org/0000-0002-0843-6568

                  Mostrar biografía de los autores

                  Antonela Sofía Asad

                  Estudiantes de doctorado del Consejo Nacional de Investigaciones Científicas y Técnicas en la Universidad de Buenos Aires.

                  Especialistas en inmunoterapia y terapia génica contra el glioblastoma y cáncer de mama en el Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

                  Camila Florencia Zuccato

                  Estudiantes de doctorado del Consejo Nacional de Investigaciones Científicas y Técnicas en la Universidad de Buenos Aires.

                  Especialistas en inmunoterapia y terapia génica contra el glioblastoma y cáncer de mama en el Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

                  Alejandro Javier Nicola Candia

                  Estudiantes de doctorado del Consejo Nacional de Investigaciones Científicas y Técnicas en la Universidad de Buenos Aires.

                  Especialistas en inmunoterapia y terapia génica contra el glioblastoma y cáncer de mama en el Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

                  María Florencia Gottardo

                  Estudiante de postdoctorado del Consejo Nacional de Investigaciones Científicas y Técnicas en la Universidad de Buenos Aires.

                  Especialista en oncología en el Laboratorio de Oncología Molecular de la Universidad de Quilmes, Bernal, Argentina.

                  Mariela Alejandra Moreno Ayala

                  Estudiante de postdoctorado. Especialista en oncología del Departamento de Biología Celular y Molecular, University of California, Berkeley, CA, USA.

                  María Susana Theas

                  Investigadora independiente del Consejo Nacional de Investigaciones Científicas y Técnicas. Especialista en fertilidad masculina en el Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

                  Adriana Seilicovich

                  Investigadora Superior del Consejo Nacional de Investigaciones Científicas y Técnicas. Especialista en endocrinología en el Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

                  Marianela Candolfi

                  Investigadora Independiente del Consejo Nacional de Investigaciones Científicas y Técnicas. Especialista en inmunoterapia y terapia génica contra el glioblastoma y cáncer de mama en el Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

                  La humanina es un péptido derivado de la mitocondria con efectos protectores robustos contra una gran variedad de estímulos citotóxicos en diversos tipos celulares. Esto la convierte en un blanco terapéutico interesante para muchas enfermedades, como el cáncer y enfermedades neurodegenerativas, entre otras. Además, este péptido podría utilizarse como un biomarcador en estas enfermedades. Durante la última década, han sido desarrollados análogos y péptido-miméticos de  la  humanina  que  muestran  resultados  prometedores en modelos preclínicos. A su vez, también se está explorando el potencial terapéutico de vectores de terapia génica que puedan sobreexpresar o silenciar la humanina endógena. Varios  puntos importantes a  considerar antes de  trasladar estas estrategias terapéuticas    a la clínica son su posible papel en la progresión del cáncer y la eventual generación de quimiorresistencia. Todos estos temas serán abordados en este artículo de revisión.

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