Determinación de deleciones en el cromosoma Y en hombres infértiles candidatos a técnicas de reproducción asistida

Determination of microdeletion in chromosome Y in infertile men, candidates to assistedreproduction techniques Intracytoplasmatic spermatozoid Injection

Publicado 2004-12-31

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Vol. 2 Núm. 2 (2004)
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Artículo Original
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Lucena Q, E., Pérez, C. E., & Kent First, M. (2004). Determinación de deleciones en el cromosoma Y en hombres infértiles candidatos a técnicas de reproducción asistida. REVISTA NOVA , 2(2). https://doi.org/10.22490/24629448.3
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https://doi.org/10.22490/24629448.3
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Así mismo,  los autores mantienen sus derechos de propiedad intelectual sobre los artículos.  

Elkin Lucena Q
Unidad de Biogenética Molecular Reproductiva. Centro Colombiano de Fertilidad y Esterilidad. CECOLFES. Bogotá D.C., Colombia.
    Clara Esteban Pérez
    Unidad de Biogenética Molecular Reproductiva. Centro Colombiano de Fertilidad y Esterilidad. CECOLFES. Bogotá D.C., Colombia.
      Marijo Kent First
      2Universidad de Wisconsin y Corporación PROMEGA Madison E.U.
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        El compromiso espermático severo en el hombre infértil, puede ser el resultado de la presencia de deleciones en el cromosoma Y en la región AZFc (Factor de azoospermia región c). En este estudio se caracterizaron 97 hombres con infertilidad con una frecuencia del 6% para la presencia de deleciones en la población estudiada. De estos hombres positivos para deleción en la región Yq (AZFc), nacieron tres niños mediante el uso de inyección intracitoplasmática (ICSI) que heredaron la mutación en el cromosoma Y, fundamentando la importancia de crear un programa de tamizaje para detectar la presencia de deleción en este cromosoma en la población de hombres infértiles candidatos para técnica de fertilización asistida (ART) mediante ICSI. Palabras claves: hombres infértiles, delección, Zona Yq, fertilización asistida, inyección intracitoplasmática de espermatozoides.

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        64. -------------------------------------------------------------------------------
        65. DOI: http://dx.doi.org/10.22490/24629448.3
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